No dose reduction is required in patients with mild to moderate renal impairment (i.e. In dialysis patients with severe renal failure, the dose should not exceed 7.5 mg (half a 15 mg tablet) per day. Patients with increased risks for adverse reactions should start treatment with 7.5 mg per day. The recommended dose for long term treatment of rheumatoid arthritis and ankylosing spondylitis in elderly patients is 7.5 mg (half a 15 mg tablet) per day. Water may be used to moisten the buccal mucosa in patients with a dry mouth.Įlderly patients and patients with increased risks for adverse reaction : Melodyn Orodispersible Tablets should be placed in the mouth on the tongue and allowed to dissolve slowly for five minutes (the tablet should not be chewed and should not be swallowed undissolved), before swallowing with a drink of 240 ml of water. The patient's need for symptomatic relief and response to therapy should be re-evaluated periodically, especially in patients with osteoarthritis. Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control symptoms. Rheumatoid arthritis, Ankylosing Spondylitis: 15 mg/day (one 15 mg tablets).Īccording to the therapeutic response, the dose may be reduced to 7.5 mg/day (half a 15mg tablet). Exacerbations of Osteoarthritis: 7.5 mg/day (half a 15 mg tablet) if necessary, in the absence of improvement, the dose may be increased to 15 mg/day.
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